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The rate of discontinuation due to adverse events varied from 5% to 19%, predominantly due to gastrointestinal side effects [17]

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NICE guidance (NG193) advises against using opioids or gabapentinoids (gabapentin, pregabalin) for chronic primary pain due to limited evidence of benefit and potential for harm

Early clinical studies of Retatrutide have reported impressive weight-loss outcomes, making it one of the most closely watched medications in obesity medicine

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