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Due to its potential side effects and risks, Qsymia should only be used under the supervision of a healthcare professional and is typically recommended for individuals with a body mass index (BMI) of 30 or higher, or those with a BMI of 27 or higher with weight-related comorbidities

In addition, overdose APAP induces mitochondrial oxidative stress, which results in mitochondrial dysfunction and cell death (Figure 3) [140]

Intrinsic apoptosis is initiated under exposure to internal stimuli, such as growth factor deprivation, hypoxia, DNA damage, oxidative stress, and calcium overload 98

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Hence, these disorders, which are inherited as monogenic disorders, are referred to as familial chylomicronemia syndromes, as hypertriglyceridemias, as hyperlipoproteinemias, and as hyperlipidemias