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In recent years, glutathione has gained popularity as a skin-lightening agent due to its ability to inhibit melanin production, the pigment that gives skin its colour

There is also a high degree of heterogeneity among participants of the analyzed studies

While these changes typically require extended exposure at high levels, they represent a real risk of excessive or prolonged use

In contrast, therapeutic strategies targeting other HSPs, including HSP70, HSP27, and B-crystallin, remain at an earlier stage but have demonstrated encouraging results in preclinical cardiovascular models

Collectively, above evidence shows that natural products may serve as effective therapeutic agents in DKD management