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Preclinical studies revealed that dapagliflozin activates the SIRT6FOXO3 pathway to reduce myocardial fibrosis and oxidative damage in diabetic cardiomyopathy models (Ma et al., 2024)

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16 Despite increases in NAC concentrations, there was no observed increase in CSF total or reduced GSH concentrations, presumably because the conversion of NAC to GSH occurs intracellularly

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