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Since exogenous supplementation of GSH is not effective, modulation of glutathione biosynthesis by withanolide A could be of much therapeutic interest and can be used as a prophylactic to prevent/cure neurodegenerative disorders invoked by elevated oxidative insults in hypobaric hypoxia and other similar pathological condition

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The "GHK" designation comes from the single-letter amino acid codes: G = Glycine H = Histidine K = Lysine (using K because L was already assigned to Leucine) Natural Occurrence and Age-Related Decline In human plasma, GHK-CU levels start at approximately 200 ng/mL at age 20

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