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Without clinical approval, clear safety data, or regulation, the risks far outweigh the short-term gains
Storage Keep tightly closed in a cool, dry place
Orally delivered NAC undergoes extensive first-pass metabolism resulting in about 90% loss by enzymatic deacetylation to form cysteine in the small intestine [9]
Future investigations should incorporate high-resolution joint-tissue single-cell transcriptomics, long-term OA models, and clinically stratified cohorts to further elucidate the diagnostic utility and mechanistic function of LPCAT3 in OA pathogenesis
Nat Prod Res 34(18):26072611 Rudrapal M, Khairnar SJ, Khan J, Dukhyil AB, Ansari MA, Alomary MN et al (2022) Dietary polyphenols and their role in oxidative stress-induced human diseases: insights into protective effects, antioxidant potentials and mechanism(s) of action
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