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Rypdal, K
10.1016/S2215-0366(22)00237-1 Lancet Psychiatry
In a hybrid in-silico/in-vitro study, we aimed to (i) design and apply protocols mimicking glucose and amino-acid variations during meals on primary and iPSC-derived islets, (ii) measure on-line the corresponding cell electrical activity and coupling, (iii) build a mathematical model of islets based on these data, and (iv) introduce this model into an FDA-approved human multiorgan simulator of glucose homeostasis (UVA-PADOVA)
This distinction is pivotal since clinical oversight and support for diabetes go beyond what telehealth appointments can offer
But when stores become depleted, the body may have a harder time keeping up with inflammation and cellular repair processes
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