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In an extended review, it was highlighted that some preclinical gene-therapy approaches delivering exogenous antioxidant enzymes, via viral vectors or nanozyme platforms, in animal models of hyperglycemic bone defects, significantly reduced inflammation, limited ROS-mediated damage, and improved healing outcomes (Li et al., 2024)

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Furthermore, ROS cause oxidative damage to protein, lipid, and DNA and induces genomic instability, promoting tumor initiation and malignant progression (10)

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But what exactly can it do, and how does it work for hyperpigmentation