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Some studies , conducted on mice, showed that semaglutide crossing the blood-brain barrier might increase the ventral tegmental area (VTA) dopamine neuron activity, thus reducing appetite and cravings for other activities like drinking
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When cytoplasmic catecholamine concentrations rise to levels that threaten to saturate both VMAT2 sequestration and mitochondrial monoamine oxidase (MAO) degradation pathways, the reversal of plasma membrane transporters provides a vital escape route (Underhill et al., 2021)
It can only be accessed in the UK through participation in an approved clinical trial at a registered research site
ISSN 0006-3002
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