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Researchers planning new work should review the most current literature directly, with attention to the gap between the older sleep claims and the open mechanistic questions

ROS regulates MAPK and NF-B signaling pathways, further affecting cell proliferation, angiogenesis, and apoptosis in joints (173)

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222 However, poor solubility and stability restrict its therapeutic application, necessitating the development of nanocarriers or other delivery strategies to improve bioavailability