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Annu Rev Nutr 41:4977 Qiu H, Novikov A, Vallon V (2017) Ketosis and diabetic ketoacidosis in response to SGLT2 inhibitors: Basic mechanisms and therapeutic perspectives

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Clinical trials show average weight loss of 15 to 20% of body weight over 12 to 18 months, with some people losing more

Provided the findings in this study are genuine, the observed cardiorenal risk benefits of combination therapy of SGLT2 inhibitors and GLP-1 RAs compared with monotherapy may stem from their distinct and potentially synergistic mechanisms of action