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Cancer-associated fibroblasts in osteosarcoma: Key players in immune escape and targeted therapy

To determine the specific acyl-carnitine species that were consistently elevated across the subgroup of patients with consistently abnormal acyl-carnitine panels, we examined the first two acyl-carnitine panels measured for each patient

Personal model-assisted identification of NAD+ and glutathione metabolism as intervention target in NAFLD

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Our work provides an understanding of how age-associated cognitive decline in older humans is linked to glutathione deficiency, increased oxidative stress, mitochondrial dysfunction, abnormal glucose metabolism and insulin resistance, inflammation and low levels of neurotrophic or neuron-supporting factors, and that supplementing GlyNAC reverses these defects and improves cognition. Human studies only permit measurements at the whole-body level, so in this study the researchers studied mice to investigate defects directly in the aging brain