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Mice with hepatocellular carcinoma and treated with XL413 (100 mg/kg) in combination with AZD8055 (20 mg/kg) exhibited significantly greater tumor mass reduction and increased lifespan compared to mice treated with monotherapy using either of these drugs [136]

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In brief, 500 cells were seeded per well in 384-well plates, and after 24 h, the medium was switched using a series of 4 aspirationwash steps with the desired final medium

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