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guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom A61K31/44Non condensed pyridines
Current estimates suggest: Approximately 900,000 people living with dementia in the UK (Alzheimer's Society) Two-thirds of these have Alzheimer's disease (approximately 600,000 people) Projected to rise to 1.6 million by 2040 as the population ages Healthcare and social care costs exceed 26 billion annually Informal caregiving burden is enormous, affecting family members' employment and wellbeing This disease burden explains why the NHS and research community continue pursuing disease-modifying treatments, despite repeated setbacks like the LIFT-AD trial failure
(2007) 150:10911.e102
J Tehran Univ Heart Center 10(2):74 DiNicolantonio JJ, Lavie CJ, Fares H, Menezes AR, OKeefe JH, Elsevier Ltd (2013) L-Carnitine in the secondary prevention of cardiovascular disease: systematic review and meta-analysis
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