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As BALB/c mice are melatonin deficient but receptor competent (28), this model allows for the assessment of receptor-mediated versus receptor-independent effects of exogenous melatonin administration in the context of ILC2-driven allergic airways disease
In practice, this involves giving an initial 4 g IV infusion of pyridoxine, followed by repeated 1 g IM injections every 30 minutes until the total matched dose is reached
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What If I'm Tested for Performance-Enhancing Substances
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