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It's the most physiologic option the GH pulse you get on Sermorelin mimics what a healthy younger pituitary would produce on its own

# IGF-1 LR3 for Muscle Growth: Dosing, Cycles, and How to Stack It IGF-1 LR3 (Insulin-Like Growth Factor-1 Long R3) is a modified analog of native IGF-1 that holds a unique position in the peptide stack: it acts directly at the IGF-1 receptor with a much longer half-life (~2030 hours) than the natural version, which clears in under 15 minutes

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Different stimuli can activate different MAPK pathway members, and have different downstream targets