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The answer is that these approaches are often complementary rather than competitive
Structural basis for the binding of the anticancer compound 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol to human glutathione s-transferases
Your unstimulated baseline is not zero, which compresses the measurable agonist window and makes an inverse agonist a more informative control than vehicle alone
Presented for research literature review only Dekant W (1996)
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