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Adequate hydration preserves GLP-1's kidney-protective benefits while avoiding the dehydration-related stress that could temporarily elevate kidney markers

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Furthermore, 2 weeks of subcutaneous infusion of nesfatin-1 improves glucose tolerance and insulin sensitivity in chow-fed and HFD-fed mice 227 , likely due to the direct action of nesfatin-1 on beta cells and not gutbrain signaling, similar to other peptides, such as GLP-1 and CCK 227,233,234

The -oxidation is normally responsible for only a small component of VPA metabolism (Fig