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The choice between these methods may depend on the nature and location of the wound, as well as individual patient factors
The landmark 2017 Cell study (Baar MP et al., PMID: 28340339) demonstrated that: (1) FOXO4 protein specifically accumulates in senescent cells where it binds to p53 and prevents p53 from triggering apoptosis (this is the specific mechanism being targeted)
Bone healing: Less studied than soft tissue, but promising
Marks are less fine (0.1 mL), so it's a bit less precise for small doses
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