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Gastric bypass in obese rats causes bone loss, vitamin D deficiency, metabolic acidosis, and elevated peptide YY
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Lster H, Miehe K, Punzel M, et al
Adding targets also adds complexity, potential off-target effects, and new safety questions the transient heart-rate rise seen with retatrutide is a concrete example of a signal that appears with the third receptor and not with the first two
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