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While you may notice some weight loss within four weeks, it can take longer to experience significant results
doi: 10.3389/fphar.2026.1754721 Received 26 November 2025 Revised 28 February 2026 Accepted 03 March 2026 Published 19 March 2026 Volume 17 - 2026 Edited by Achuthan Raghavamenon, Amala Cancer Research Centre, India Reviewed by Abdul Rahim Chethikkattuveli Salih, Terasaki Institute for Biomedical Innovation, United States Julio Plaza-Diaz, Childrens Hospital of Eastern Ontario (CHEO), Canada Updates Copyright 2026 Hu, Tian, Yang, Zhang, Zhang, Xu and Lu
Researchers collected data on weight change for up to 72 weeks
This dual approach of eating less and burning more creates significantly enhanced weight loss compared to single or dual receptor medications
Opioids: 25% lower risk Cocaine: 20% lower risk Nicotine: 20% lower risk Alcohol: 18% lower risk Cannabis: 14% lower risk For patients who already had a substance use disorder, the outcomes were even more striking
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