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By either sequential or concurrent administration of low doses of two agents, one a PDE-5 inhibitor and one a melanocortin receptor agonist, it has been found that a therapeutic effect equal to or greater than that achieved with a single high dose of either agent given as monotherapy can be obtained, without the side effects incident to high dose administration of either agent as monotherapy
Jacobson TA, Maki KC, Orringer CE, et al
There is a technology now available called microencapsulation
2005;115(3):e2906
Kohlmeyer JL, Kaemmer CA, Pulliam C, Maharjan CK, Samayoa AM, Major HJ, et al
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