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The decision to increase from 8mg to 12mg should be based on individual response, tolerability, and whether additional weight loss is needed to reach goals

Food and Drug Administration (FDA) 6 stated that there is currently no evidence of a direct relationship between semaglutide and suicidal thoughts or behaviours. Another vindicating study, published in JAMA Psychiatry7 in May 2025 and involving 107,000 participants, found that compared with placebo, treatment with GLP-1 medications was not associated with increased risk of psychiatric adverse events

But honestly, it's the bedrock of sound science

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How It Works Complete a comprehensive online intake questionnaire where you detail your medical history, weight loss goals, and eating habits