The menopausal transition (or perimenopause) begins, on average, four years before the final menstrual period
These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione
While a causal relationship remains inconclusive (patients with T2D and obesity have other pancreatitis risk factors), prudence dictates avoiding these drugs in patients with a history of pancreatitis or at least using with caution
Armed with this genetic insight, patients avoid wasting money on medications or doses that don't match their genetic predisposition, directing treatment resources toward the most effective option for their individual metabolism
Crucially, Lillys small-molecule pill is cheaper to make and scale than Novos large peptide pill