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When activated, it doesn't just signal the brain to stop eating but starts a cellular clean up process by changing how genes related to insulin sensitivity and lipid metabolism are transcribed
doi: 10.1155/2020/9067610 135 WangXMaHSunJZhengTZhaoPLiHet al
Mitochondrial sirtuin 3 (SIRT3) is a major modulator of mitochondrial metabolism and homeostasis, regulating UPR mt , mitochondrial biogenesis, mitophagy, fusion/fission, and antioxidant expression 98
Aksenov, I
10.1001/jamaoncol.2019.2109 99 ShadboorestanA.TarighiP.KooshaM.FaghihiH.GhahremaniM
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