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Some patients may notice symptoms returning before their next scheduled injection, particularly if they have higher metabolic demands or ongoing neurological involvement

A randomized cross-over trial (NCT01965756) reported no significant effects on ADAS-Cog word-list memory or CSF A/tau levels over 16 weeks, despite acceptable safety (including transient lactate elevations in 10% of participants without serious events)

The study did conclude that those who took B12 supplements were unlikely to have deficient or low B12 levels

2026 Apr 14

Arthroscopic Centralization of the Medial Meniscus Reduces Load on a Posterior Root Repair Under Dynamic Varus Loading: A Biomechanical Investigation