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That follow-up trial, involving 536 obese adults over 24 weeks, failed to meet its primary efficacy endpoint, meaning the fat-loss effect seen at the smaller scale did not hold up in the pivotal study

Self-administered intra-articular injection risks septic arthritis (joint infection), which requires emergency IV antibiotics and possible surgical drainage within 24-48 hours of onset

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Immunotherapy strategies, such as MHC/neuroantigen peptide constructs, have emerged as experimental approaches for treating METH-induced learning and memory deficits

Doubling doses is not performed