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In practice this means the first two to three months of any incretin therapy are the hardest, after which most people who were going to tolerate the drug have done so
These receptors belong to the G-protein coupled receptor familya class of proteins that span the cell membrane and trigger internal responses when activated by external signals
It works by targeting the GLP-1 (glucagon-like peptide-1) receptor, a hormone involved in appetite regulation and digestion
Many people who rely solely on GLP-1 therapy without incorporating strength training or proper nutrition experience weight regain once they stop the medication
Patient compliance with nicotinic acid administration is sometimes compromised because of the unpleasant side-effect of flushing (strong cutaneous vasodilation)
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