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Bae HL, Jeong K, Yang SJH, Kim K,Chai YJ
PMID: 842646 Kawashima K et al (1988): Direct determination of acetylcholine release by radioimmunoassay and presence of presynaptic M1 muscarinic receptors in guinea pig ileum
Consequently, NSAIDs can increase the risk of gastric irritation, ulceration, and gastrointestinal bleeding, particularly with prolonged use, higher doses, or in vulnerable populations such as older adults or those with a history of peptic ulcer disease
Be extra careful if you already have nausea, vomiting, bloating, constipation, reflux, or stomach discomfort
And we think of years lived with obesity now like smoking years lived with tobacco we're starting to think of years lived with obesity not so much to change my treatment but to render the risk estimate that you have
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