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Liraglutide also induction HO-1 expression by activating AMPK and promoting HIF-1 protein export from cytoplasm to nucleus, which significantly increases the expression of anti-apoptotic protein Bcl-2 and decreases the expression of pro-apoptotic Bax and Caspase-3 in HUVECs cells [134]
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To further evaluate the therapeutic potential of modulating lipid metabolism, we administered atorvastatin in the mouse model of CaOx crystal-induced kidney injury
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