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Use of the ergot derivative bromocriptine for lactation suppression in conjunction with a sympathomimetic (i.e., isometheptene or phenylpropanolamine) for other therapeutic uses has resulted in adverse effects such as worsening headache, hypertension, ventricular tachycardia, seizures, sudden loss of vision, and cerebral vasospasm

In the context of a restricted assay-format, in which implication of free LASSS can be excluded, the outcomes may provide critical insights towards understanding of an underlying LASSS-driven mechanism

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10.1074/jbc.R400025200 J Biol Chem