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1C, D and Supplementary Fig
However, the function and adverse side effects of these drugs will need to be carefully evaluated and used reasonably
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Under normal conditions, TNF- signaling facilitates the recruitment of RIPK1 kinase to the plasma membrane, forming membrane-associated complex , which includes RIPK1, TRADD, TNF receptor-associated factor (TRAF), and cellular inhibitors of apoptosis proteins (cIAP1/2) (Holler et al., 2000)
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