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Luo et al found that TMAO may inhibit the expression of nuclear factor E2-related factor 2 (Nrf2), HO-1, and glutathione peroxidase 4 (GPX4), resulting in the overproduction of ROS and the reduction of SOD activity, thus promoting oxidative stress
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Low levels may indicate increased vulnerability to oxidative stress and reduced ability to eliminate toxins effectively
However, vegans or vegetarians may benefit from a supplement since their diet naturally contains less of the compound, she says
Chronic Fatigue Syndrome A 2004 randomized trial demonstrated decreased fatigue severity and improved quality of life metrics in patients with chronic fatigue syndrome after 24 weeks of treatment at 2 grams daily [5][32]
