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Proc Biochem 45:441445
Viral hepatitis caused approximately 1.3 million deaths globally in 2022 , equivalent to about 3,500 deaths per day
The constipation pathway: Predominant GLP-1 receptor expression in the colon Slowed peristalsis exceeds the gut's ability to adapt Increased water absorption Hard, infrequent stools The diarrhea pathway: Predominant GLP-1 receptor expression in the small intestine Slowed small bowel transit allows bacterial overgrowth or malabsorption Osmotic load in the colon from unabsorbed nutrients Loose, frequent stools The mixed pathway (most common): Early diarrhea (weeks 1-4) from acute gastric retention and bile acid malabsorption Transition to constipation (weeks 4-12) as colonic adaptation lags behind gastric adaptation Resolution to normal or near-normal bowel habits after 12-16 weeks A 2024 paper in Gut (Acosta et al.) measured GLP-1 receptor density in colonic biopsies from 86 patients starting semaglutide
Athletes are at a greater risk of being iron deficient in comparison to the general population, especially female athletes, with up to ~35% having an iron deficiency versus ~5% in the general population
The effect of vitamin C (ascorbic acid) in the treatment of patients with cancer: a systematic review
