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First, neuropeptides were not considered neurotransmitters until years later

The immunogenicity findings have important practical implications

A May 2025 study in Molecular Therapy from the INc-UAB showed that gene therapy increasing secreted klotho (s-KL) in mice extended lifespan by 15-20% while improving muscle, bone, and cognitive health at 24 months of age (equivalent to ~70 human years)

Fatigue with tirzepatide is a commonly reported concern, though clinical trial data does not list it as a top adverse event

Patella Fracture: The kneecap bone breaks What are the symptoms of a patellar tendon injury of the knee