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It builds on the progress of earlier compounds like Semaglutide and Tirzepatide by activating three key hormonal pathways involved in appetite
248 Also, SAM has a key role in regulating liver homeostasis, and reduced levels of SAM synthesis have been detected in various chronic liver injuries, such as NAFLD
Neuroprotective effects of GLP-1R agonists GLP-1 and its mimetics can cross the BBB, therefore, are able to affect the CNS function such as cognition and neuroprotection (138)
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The findings identified a mechanism distinct from previously known appetite-control pathways as an avenue by which GLP-1s could treat other dysfunctions in reward processing, such as substance use disorder
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