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10.1016/S0735-1097(99)00216-8 J Am Coll Cardiol
GSH replenishment in human tissues is difficult due to its shorter half-life, and not easy to penetrate the plasma membrane hence use of prodrugs/precursors such as cysteine, and glycine is the most promising approach 4,45
Many disease states including Alzheimers, Parkinsons disease, and autism have been found to be associated with low glutathione levels and have been treated with glutathione precursor (N-acetyl cysteine) or various forms of glutathione
Consequently, glutathione concentration reached only 367 mg/L, notably lower than the 791 mg/L achieved under batch fermentation conditions
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