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Extension participants continued treatment for an additional 24 weeks (to 104 weeks total) and were transitioned to their maximally tolerated dose of 9 or 12 mg
9A) despite its marked effects in the inhibition of cumulative food intake (43.6 0.91% in H + G49 + ATGLi group and 28.30 2.61% in H + G49 group versus each vehicle)
Some people who plateau on tirzepatide find renewed progress after switching to semaglutide, possibly due to differences in receptor activation patterns
The reason likely relates to differences in formulation stability, excipient choice, and the structural properties of the peptide itself
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