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GIP receptor agonism is hypothesised, based on preclinical and early clinical data, to complement GLP-1 effects on insulin secretion and may influence adipose tissue metabolism, though the precise contribution in humans remains an area of active investigation
This is not unusual and reflects the complex interplay of slowed gastric emptying (which promotes constipation) and altered intestinal motility (which can trigger diarrhea)
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One of the intended effects of GLP-1 drugs is to slow stomach emptying to promote satiety this means food sits in the stomach for longer, which can force stomach acids up into the esophagus, resulting in acid reflux
As of May 2026, Shotsy includes Injection Site Stats , which provide insights into which areas of the body might experience more discomfort
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