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Paneth cell-mediated multiorgan dysfunction after acute kidney injury
This inflammatory burden contributes not only to insulin resistance but also to pain sensitization
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The hyperactive hypothalamicpituitarygonadal axis in PCOS patients results in excessive ovarian androgen production in theca cells via upregulation of CYP17A1 enzyme activity ( de novo lipid synthesis, leading to excess lipid accumulation and lipotoxicity ( 5 Inflammation and oxidative stress It has been widely accepted that chronic low-grade inflammation is involved in the pathogenesis of PCOS, mainly owing to the excessive fat accumulation observed, particularly in the visceral adipose tissues ( 6 Pathogenic signaling pathways 6.1 The PI3K/Akt signaling pathway The phosphoinositide-3 kinase/protein kinase B (PI3K/Akt) signaling pathway plays an essential role in cell survival and glucose homeostasis
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