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While it is intuitively assumed that antioxidants emerged during the GOE to defend against O 2 reactivity and toxicity caused by the accelerated oxygenation of the atmosphere, sequencing and phylogenetic analyses of antioxidant systems from ancient organisms suggests that antioxidant enzymes including SODs may have originated long before the surge of atmospheric and oceanic O 2 (Wolfe-Simon et al
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Inhibition of nitric oxide (NO), followed by arterial hypertension lead to the production of excessive reactive oxygen species (eNOS), that results in oxidative stress
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