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Concomitant administration of Cassia auriculata ethanolic leaf extract mitigates HG-induced TECs neroptosis and restores biochemical homeostasis, renal function, and structural integrity in diabetic rats (139)
Regeneration of Other Antioxidants Glutathione directly recycles and regenerates other antioxidants that have been oxidized and inactivated: Vitamin C (ascorbate): GSH reduces dehydroascorbate back to ascorbate Vitamin E (alpha-tocopherol): GSH supports regeneration of oxidized tocopheryl radical Alpha lipoic acid (ALA): GSH participates in maintaining ALA in its reduced form This regenerative cascade is what distinguishes glutathione from most other antioxidants
H 2 O 2 is detoxified by catalase and glutathione peroxidase [22, 92]
However, AGEs intervention reduces the expression of key glucose metabolic enzymesincluding HK, LDH, IDH, and G6PDalong with a decline in mitochondrial respiratory capacity
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