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World Congress of Nephrology, 2026)
They force sleep by dampening neural function
A patient losing 20-25% of body weight (typically 20-30 kg) would expect 10-20 mmHg systolic improvement based on this rule of thumb
One year out, they had kept off most of their weight loss, regaining only a small fraction of what they had lost far less than the substantial rebound typically seen after these medications are stopped
At the highest dose, nearly 60% of participants lost at least 10% of their body weight, and almost 40% lost 15% or more
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