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The researchers suggested the benefits of GLP-1s before pregnancy could be negated or attenuated by the adverse effects of GLP-1 discontinuation. They added the higher risk for gestational weight gain may contribute to the increased risk for hypertensive disorders of pregnancy and gestational diabetes given the established relationship between gestational weight gain and adverse pregnancy outcomes. Maya told Healio that many individuals are on GLP-1s before pregnancy and are benefiting tremendously. Clinicians following these patients need to know that when their patients stop these medications for pregnancy, they are at risk for greater gestational weight gain and greater risk for gestational diabetes, hypertensive disorders of pregnancy and preterm delivery, she said

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Current guidance supports stratified risk assessment based on individual patient factors rather than routine medication cessation

Purging improves over time

Common Withdrawal Symptoms Increased Appetite : Without the appetite-suppressing effects of GLP-1 medications, many individuals may find themselves feeling hungrier than before