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For women of reproductive age who may also be on metformin for PCOS, or who are pregnant or breastfeeding, the risk compounds further

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While -3 PUFAs are considered to have beneficial effects 40 , consumption of PUFAs has also been linked with more severe ALD in humans and experimental animals 41

Anecdotal reports from clinical practitioners using compounded MOTS-c describe transient facial flushing, mild nausea, and occasional loose stools within the first 48 to 72 hours of initiation