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When a second drug displaces a primary drug from its binding sites on plasma proteins, the unbound fraction For a low-extraction (restrictively cleared) drug, where u * CL int , The net effect is that the steady-state concentration of free drug, which is responsible for the therapeutic effect, remains largely unchanged, minimizing the risk of toxicity
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& Baumann, G
Do not stop or adjust thyroid medications without consulting your primary care doctor or endocrinologist
DeNicola, G.M., et al., Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
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