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This was followed by a 38-day pharmacokinetic blood sampling and safety assessment period (i.e., 45 times the estimated cagrilintide t 1/2 ), with blood samples collected on days 8, 15, 22, 29 and 39

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Consuming just one or two Brazil nuts can provide more than the recommended daily intake of selenium, and eating large amounts regularly may lead to adverse effects [7] , such as: Bad breath Diarrhoea Nausea Brittle hair and nails Skin rashes Joint pain Irritability Tiredness Dizziness In severe cases, extreme selenium toxicity, usually from supplements or unusually high consumption, can cause severe effects sometimes resulting in kidney failure, heart attack, or heart failure [8]