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MarchiNAngelovLMasarykTFazioVGranataTHernandezNet al
doi: 10.1371/journal.pone.0233208 106 MakhezerNBen KhemisMLiuDKhichaneYMarzaioliVTliliAet al
They found only one small exploratory ulcerative-colitis study with too little detail for firm conclusions, no clinical studies in Crohn's disease, and continuing concerns about product quality and safety
It takes two conversion steps to become active: retinol retinal retinoic acid
This combination makes it relevant not just for aesthetic outcomes but for the broader inflammatory burden that accelerates aging in metabolically active tissues
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