Treatment with the selective GLS1 inhibitor BPTES reduced glycolysis and ameliorated lupus-like disease and EAE in MRL/lpr mice ( + CD4 - CD8 - cells), the urinary albumin/creatinine ratio, glomerular nephropathy score, and T-cell infiltration with IL-17A in the kidneys, relieving the EAE disease activity ( + T cells by inhibiting GLS1, glycolysis, and CD4 + T-cell differentiation in vitro by reducing the level of HIF1 protein, a key metabolic sensor in Th17 cells ( Table 1 )
However, as GLP-1s originally intended to treat Type 2 diabetes (T2D) and often delivered with injection pens developed for insulin are increasingly used to treat obesity, perhaps it is worth rethinking the basis of these designs to accommodate a user group that may have different requirements
Suitable as supportive therapy for chronic kidney disorders under medical supervision
Conjugated Linoleic Acid burns body fat and helps to build muscle mass
Zapala L, Juszczak K, Adamczyk P, et al