A 2022 study in Diabetes, Obesity and Metabolism showed that NNMTi treatment combined with reduced-calorie diet "promoted dramatic whole-body adiposity and weight loss in diet-induced obese mice, rapidly normalizing" weight parameters
You might be suffering the symptoms of B12 deficiency, or you might know that you are at increased risk of B12 deficiency as a result of hereditary factors or other health conditions
Mouse metabolism, mouse fat biology, and mouse dosing all differ from the human versions, and metabolic findings in rodents have a long history of not carrying over cleanly to people
Its effect is gradual and appears most pronounced when combined with a caloric deficit and regular physical activity
In fact, its been found that B12 supplements taken orally are just as effective as intramuscular shots in overcoming states of deficiency when you take up to 1,000 micrograms a day